Understanding Fontan Biology
A molecular and cellular perspective on cardiovascular research
Our Vision
Fontan circulation creates both physiological and metabolic challenges. Fontanomics investigates these abnormalities at molecular and cellular levels to develop targeted therapies that improve patient lives.
Research Focus Areas
Four interconnected research topics advancing our understanding of Fontan circulation
Topic 1: Molecular Foundations
A return to basic physiology and biochemistry is key to address the unique challenges in Fontan circulation.
Primary aimTo develop mechanistic approaches to comprehend altered core physiological and biological processes in patients with a Fontan circulation.
Secondary aimTo reveal links between small molecule analytes on biochemistry basis, on transcriptomic and genomic basis that drive Fontan-related comorbidities and circulatory failure.
Topic 2: The Fontan Radar
Omics technologies are medical revolution. They are key to unraveling the complex origins of Fontan-related comorbidities.
Better biomarkersWe are also exploring the full potential of existing biomarkers, whether they are published in literature on Fontan circulation and general cardiology.
AimTo develop an accurate prognosis: By strategically employing biomarkers, we aim to improve diagnostics, foresee long-term complications, and predict major adverse events with accuracy.
Topic 3: Cardiac Metabolism
Metabolic and regulatory processes, including oxidative stress, inflammation, and immunity, are determining Fontan outcomes.
AimWe are integrating hemodynamic and metabolic evaluations to create a more complete picture of Fontan pathophysiology.
Topic 4: Metabolic Therapies
Our consortium intends advancing clinical trials focused on metabolic interventions for selected subgroups of patients with a Fontan circulation.
AimTo develop a comprehensive approach that extends from traditional therapies to lifestyle medicine for sustained quality of life.