Understanding Fontan Biology
A molecular and cellular perspective on cardiovascular research
Our Vision
Fontan circulation creates both physiological and metabolic challenges. Fontanomics investigates these abnormalities at molecular level to develop targeted therapies that improve patient lives.
proteomics analysis
Research Focus Areas
Our interconnected research topics advancing our understanding of Fontan circulation
Topic 1: Molecular Foundations
A return to basic physiology and biochemistry is key to address the unique challenges in Fontan circulation.
Primary aimTo develop mechanistic approaches to comprehend altered core biological processes in patients with a Fontan circulation.
Secondary aimsTo reveal links between small molecule analytes on biochemistry basis, on transcriptomic and genomic basis that regulates Fontan circulation.
Topic 2: The Fontan Radar
Omics technologies are medical revolution. They are key to unraveling the complex origins and interconnections of Fontan-related comorbidities.
Primary aimWe are also exploring the full potential of existing biomarkers, whether they are published in literature on Fontan circulation and general cardiology.
Secondary aimsTo develop an accurate prognosis: By strategically employing biomarkers, we aim to improve diagnostics, monitor risk stratification, and outcome prediction.
Topic 3: Cardiac Metabolism
Metabolic and regulatory processes, including energy metabolism, oxidative stress, inflammation, immunity, and endothelial function are determining Fontan outcomes.
AimWe are integrating hemodynamic and metabolic evaluations to create a comprehensive picture of Fontan pathophysiology.
Topic 4: Targeted Metabolic Therapies
Our research group intends advancing clinical trials focused on metabolic interventions for selected subgroups of patients with a Fontan circulation.
AimTo develop a comprehensive approach that extends from established palliative medical therapy to a targeted metabolic therapy for improved quality of life.