Publications

Our research contributions advancing the understanding of Fontan circulation through molecular biology, metabolism studies, and therapeutic development.

Phase A (20 patients + 20 controls)

Research
Lipidomics

Targeted metabolomic analysis of serum phospholipid and acylcarnitine in the adult Fontan patient with a dominant left ventricle

Michel M, Dubowy KO, Zlamy M, Karall D, Adam MG, Entenmann A, Keller MA, Koch J, Odri Komazec I, Geiger R, Salvador C, Niederwanger C, Müller U, Scholl-Bürgi S, Laser KT.
Ther Adv Chronic Dis.
2020 Apr 27;11:2040622320916031
doi: 10.1177/2040622320916031
Research
Metabolomics

Targeted metabolomic analysis of serum amino acids in the adult Fontan patient with a dominant left ventricle

Michel M, Dubowy KO, Entenmann A, Karall D, Adam MG, Zlamy M, Odri Komazec I, Geiger R, Niederwanger C, Salvador C, Müller U, Laser KT, Scholl-Bürgi S
Sci Rep.
2020 Jun 2;10(1):8930
doi: 10.1038/s41598-020-65852-x
Research
Omics Methodology

Method comparison of HPLC-ninhydrin-photometry and UHPLC-PITC-tandem mass spectrometry for serum amino acid analyses in patients with complex congenital heart disease and controls

Michel M, Salvador C, Wiedemair V, Adam MG, Laser KT, Dubowy KO, Entenmann A, Karall D, Geiger R, Zlamy M, Scholl-Bürgi S.
Metabolomics.
2020 Dec 15;16(12):128
doi: 10.1007/s11306-020-01741-8
Research
Omics Methodology

Metabolomics and random forests in patients with complex congenital heart disease

Michel M, Laser KT, Dubowy KO, Scholl-Bürgi S, Michel E.
Front Cardiovasc Med.
2022 Oct 5;9:994068
doi: 10.3389/fcvm.2022.994068
Review
Cardiac Metabolism

Comparative Metabolomics in Single Ventricle Patients after Fontan Palliation: A Strong Case for a Targeted Metabolic Therapy

Renaud D, Scholl-Bürgi S, Karall D, Michel M.
Metabolites.
2023 Aug 9;13(8):932
doi: 10.3390/metabo13080932
Research
Proteomics

Altered Serum Proteins Suggest Inflammation, Fibrogenesis and Angiogenesis in Adult Patients with a Fontan Circulation

Michel M, Renaud D, Schmidt R, Einkemmer M, Laser LV, Michel E, Dubowy KO, Karall D, Laser KT, Scholl-Bürgi S.
Int J Mol Sci.
2024 May 16;25(10):5416
doi: 10.3390/ijms25105416

Related Works

Review

Impact of the Fontan Operation on Organ Systems

Miriam Michel, Manuela Zlamy, Andreas Entenmann, Karin Pichler, Sabine Scholl-Bürgi, Daniela Karall, Ralf Geiger, Christina Salvador, Christian Niederwanger, Hideo Ohuchi
Cardiovasc Hematol Disord Drug Targets
2019
doi: 10.2174/1871529X19666190211165124
Research
Metabolomics

Amino Acid and Phospholipid Metabolism as an Indicator of Inflammation and Subtle Cardiomyopathy in Patients with Marfan Syndrome

Bartenbach, L.; Karall, T.; Koch, J.; Keller, M.A.; Oberacher, H.; Scholl-Bürgi, S.; Karall, D.; Oemer, G.; Baumgartner, D.; Meinel, K.; et al.
Metabolites.
2021 Nov 27;11(12):805
doi: 10.3390/metabo11120805
Research

Influence of Respiration on Collateral Flow in the Fontan Population Using Real-time Phase-contrast Cardiovascular Magnetic Resonance: Collateral Flow Does Not Protect the Ventricle From Volume Deficiency and Diastolic Dysfunction

Blessing M, Körperich H, Barth P, Michel M, Dubowy O, Forreiter S, Laser KT.
J Thorac Imaging
2023 Sep 1;38(5):W64-W74
doi: 10.1097/RTI.0000000000000684
Review
Metabolic Therapy

Ketogenic diets in patients with inherited metabolic disorders

Scholl-Bürgi S, Höller A, Pichler K, Michel M, Haberlandt E, Karall D.
J Inherit Metab Dis.
2015 Jul;38(4):765-73
doi: 10.1007/s10545-015-9872-2