Research Topics
Our comprehensive approach integrates molecular biology, hemodynamics, metabolism, and therapeutic development to advance our understanding of Fontan circulation.
Topic 1: Molecular Foundations
Reimagining the fundamentals – "Coming back to the blackboard"
A return to basic physiology and biochemistry is key to address the unique challenges in Fontan circulation. Developing mechanistic approaches to comprehend altered core biological processes and revealing links between small molecule analytes on biochemical, transcriptomic, and genomic basis.
Topic 2: The Fontan radar
Harnessing the power of advanced Biomarkers and Omics
Omics technologies represent a medical revolution, key to unraveling the complex origins and interconnections of Fontan-related comorbidities. Exploring the full potential of existing biomarkers for improved diagnostics, risk stratification, and outcome prediction.
Topic 3: Cardiac Metabolism
Metabolism: a major factor determining outcomes in Fontan?
Metabolic and regulatory processes, including energy metabolism, oxidative stress, inflammation, immunity, and endothelial function are determining Fontan outcomes. Integrating hemodynamic and metabolic evaluations for a comprehensive understanding.
Topic 4: Targeted metabolic Therapies
Pioneering development of Fontan targeted metabolic therapies
Expanding treatment options to live a full life with half a heart. Our consortium advances clinical trials focused on metabolic interventions for selected Fontan patient subgroups.